HSR-IN-1

HSR-IN-1 (Compound 28) is an effective hSR (human serine racemase) inhibitor. In the presence of the cofactor Pyridoxal 5'-phosphate monohydrate (HY-W011727A), HSR-IN-1 has a Kd value of 5.4 μM and an IC50 of 18.3 μM for hSR, while the IC50 of HSR-IN-1 alone is 4.7 μM. HSR-IN-1 can be used for research on central nervous system diseases[1].

Product Specifications

UNSPSC

12352211

Target

Serine Racemase (SR)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hsr-in-1.html

Smiles

[NH3+]OC(C(O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1.[Cl-]

Molecular Formula

C15H16ClNO3

Molecular Weight

293.75

References & Citations

[1]Marchesani F, et al. Chemical Probes to Investigate Central Nervous System Disorders: Design, Synthesis and Mechanism of Action of a Potent Human Serine Racemase Inhibitor[J]. ACS Medicinal Chemistry Letters, 2024.