JPS014 (TFA)
JPS014 TFA is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC) . JPS014 TFA degrades class I histone deacetylase (HDAC) . JPS014 TFA is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; HDAC; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jps014-tfa.html
Purity
98.12
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)CCCCCCCCOCC(NC4=CC=C(C(NC5=CC=CC=C5N)=O)C=C4)=O.OC(C(F)(F)F)=O
Molecular Formula
C48H60F3N7O9S
Molecular Weight
968.09
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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