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Human IL-18BP ELISA Kit PicoKine®, Carrier-free

Selected Variant

EK1282-carrier-free

Size: 96 Well With Removable Strips

Human IL-18BP ELISA Kit PicoKine® (96 Tests). Quantitate Human IL18BP in cell culture supernatants, serum, plasma (heparin, EDTA) and urine. Sensitivity: 10pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

Product Specifications

Background

Interleukin-18-binding protein, also known as IL18BPa, is a protein that in humans is encoded by the IL18BP gene. It is mapped to 11q13.4. The protein encoded by this gene is an inhibitor of the proinflammatory cytokine IL18. This protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. This protein is constitutively expressed and secreted in mononuclear cells. The expression of this protein can be enhanced by IFN-gamma. It has been found that IL18BP expression in intestinal tissue is increased in endothelial cells as well as cells of the submucosa and overlying lymphoid aggregates in Crohn disease.

Reproducibility

<table cellpadding="3"><tr><th>Lots</th><th>Lot 1 (pg/ml)</th><th>Lot 2 (pg/ml)</th><th>Lot 3 (pg/ml)</th><th>Lot 4 (pg/ml)</th><th>Mean (pg/ml)</th><th>Standard Deviation</th><th>CV (%)</th></tr><tr><td>Sample 1</td><td>122</td><td>128</td><td>142</td><td>139</td><td>132</td><td>8.1</td><td>6.1%</td></tr><tr><td>Sample 2</td><td>924</td><td>885</td><td>907</td><td>868</td><td>896</td><td>21.27</td><td>2.3%</td></tr><tr><td>Sample 3</td><td>2127</td><td>2341</td><td>2469</td><td>2295</td><td>2308</td><td>122.41</td><td>5.3%</td></tr></table>*number of samples for each test n=16.

Synonyms

Interleukin-18-binding protein;IL-18BP;Tadekinig-alfa;IL18BP;

Gene Name

Interleukin-18-binding protein

Gene ID

10068

UniProt

O95998

Reactivity

Human

Cross Reactivity

There is no detectable cross-reactivity with other relevant proteins.

Immunogen

Expression system for standard: NS0; Immunogen sequence: T31-G194

Tissue Specificity

Strongly expressed in heart, lung, placenta and spleen. .

Applications

ELISA

Standard

10 ng/tube

Sample Type

cell culture supernatants, serum, plasma (heparin, EDTA) and urine.

Detection Range

93.7 pg/ml - 6,000 pg/ml

Sensitivity

<10 pg/ml

Function

Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. .

Components

Description|Quantity Pre-coated 96-well strip microplate|1 Standard|2 vials Biotinylated antibody (100x)|100ul Avidin-Biotin-Peroxidase Complex (100x)|100ul Sample Diluent|30ml Antibody Diluent|12ml Avidin-Biotin-Peroxidase Diluent|12ml Color Developing Reagent (TMB)|10ml Stop Solution|10ml Wash Buffer (25x)|20ml Adhesive plate sealers|4

Storage Conditions

Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Calculated Molecular Weight

21099 MW

Specificity

Natural and recombinant human IL-18BP

Anticoagulant

heparin or EDTA

Subcellular Location

Secreted .

Sequence Similarities

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Protein Name

Interleukin-18-binding protein

Price

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