Anti-SPRYD2 CMYA5 Antibody

Boster Bio Anti-SPRYD2 CMYA5 Antibody (Catalog # A08262) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.

Synonyms

SPRYD2, TRIM76, C5orf10, DTNBP2, SPRYD2, Cardiomyopathy-associated protein 5, Dystrobrevin-binding protein 2

Gene Name

CMYA5

UniProt

Q8N3K9

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

SPRYD2 antibody is predicted to not cross-react with other SPRYD protein family members. At least four isoforms of SPRYD2 are known to exist.

Immunogen

SPRYD2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human SPRYD2. The immunogen is located within amino acids 3810 - 3860 of SPRYD2.

Clonality

Polyclonal

Tissue Specificity

Expressed in skeletal muscle; at a strong level and in heart.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Homeostasis

Purification

SPRYD2 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity) . May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity) . .

Molecular Weight

449211 MW

Shipping Conditions

Available

Storage Conditions

SPRYD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A08262

Product MSDS

https://www.bosterbio.com/msds?sku=A08262

Fragment

IgG

Other Gene Names

Cardiomyopathy associated 5

Subcellular Location

Cytoplasm . Cytoplasm, perinuclear region . Cytoplasm, myofibril, sarcomere, M line

Protein Name