YM-298198 (hydrochloride)

YM-298198 hydrochloride is a high-affinity, selective, orally active, and non-competitive antagonist of metabotropic glutamate receptor type 1 (mGluR1) . YM-298198 hydrochloride can be used for the research of neurological disorders[1].

Product Specifications

CAS Number

[1216398-09-2]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ym-298198-hydrochloride.html

Purity

99.0

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C(C)N2C3=CC(N)=CC=C3N=C2S1)N(C4CCCCC4)C.[H]Cl

Molecular Formula

C18H23ClN4OS

Molecular Weight

378.92

Precautions

H315, H319, H320

References & Citations

[1]Kohara, A, et al. Radioligand Binding Properties and Pharmacological Characterization of 6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a High-Affinity, Selective, and Noncompetitive Antagonist of Metabotropic Glutamate Receptor Type 1. J Pharmacol Exp Ther. 2005 Oct;315 (1) :163-9.