Diosbulbin C
Product Specifications
UNSPSC Description
Diosbulbin C is a diterpene lactone component, which can be extracted from traditional Chinese medicine Dioscorea bulbifera L.. Diosbulbin C possesses high anticancer activity in non-small cell lung cancer (NSCLC). Diosbulbin C could induce cell cycle arrest at G0/G1 phase in NSCLC. Diosbulbin C also inhibits the proliferation of NSCLC cells, possibly by downregulating the expression/activation of AKT, DHFR, and TYMS[1][1].
Target Antigen
Akt; Dihydrofolate reductase (DHFR) ; Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease;PI3K/Akt/mTOR
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/diosbulbin-c.html
Smiles
O=C([C@@H]1C[C@H](O)C[C@@]2([H])[C@@]3(C)[C@@](O[C@@H](C4=COC=C4)C3)(C5)C(O[C@]5([H])[C@@]21[H])=O)O
Molecular Weight
362.37
References & Citations
[1]Zhu Z, et al. Diosbulbin C, a novel active ingredient in Dioscorea bulbifera L. extract, inhibits lung cancer cell proliferation by inducing G0/G1 phase cell cycle arrest. BMC Complement Med Ther. 2023 Dec 4;23(1):436.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N3764/Diosbulbin-C-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N3764/
Clinical Information
No Development Reported
CAS Number
20086-07-1
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