Diosbulbin C

Diosbulbin C is a diterpene lactone component, which can be extracted from traditional Chinese medicine Dioscorea bulbifera L.. Diosbulbin C possesses high anticancer activity in non-small cell lung cancer (NSCLC) . Diosbulbin C could induce cell cycle arrest at G0/G1 phase in NSCLC. Diosbulbin C also inhibits the proliferation of NSCLC cells, possibly by downregulating the expression/activation of AKT, DHFR, and TYMS[1][1].

Product Specifications

CAS Number

[20086-07-1]

UNSPSC

12352005

Target

Akt; Dihydrofolate reductase (DHFR) ; Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/diosbulbin-c.html

Smiles

O=C([C@@H]1C[C@H](O)C[C@@]2([H])[C@@]3(C)[C@@](O[C@@H](C4=COC=C4)C3)(C5)C(O[C@]5([H])[C@@]21[H])=O)O

Molecular Formula

C19H22O7

Molecular Weight

362.37

References & Citations

[1]Zhu Z, et al. Diosbulbin C, a novel active ingredient in Dioscorea bulbifera L. extract, inhibits lung cancer cell proliferation by inducing G0/G1 phase cell cycle arrest. BMC Complement Med Ther. 2023 Dec 4;23 (1) :436.