DPyPE

DPyPE is a neutral phosphatidylethanolamine lipid composed of a polyisoprene alkyl chain with two pyridine-containing phosphine ligands. DPyPE is mainly used in liposome formulations and to enhance the efficiency of gene delivery in vitro and in vivo. For example, DPyPE can be mixed with cationic lipids such as VC1052 (HY-156616) (in a 1:1 ratio) to form the vaccine adjuvant Vaxfectin (HY-142998) . DPyPE assists VC1052 in binding to negatively charged pDNA to form a uniform liposome complex by regulating the fluidity and stability of the liposome membrane[1][2].

Product Specifications

CAS Number

[201036-16-0]

UNSPSC

12352211

Hazard Statement

H225, H302, H310, H315, H319, H331, H351, H361, H370, H372

Target

Liposome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/dpype.html

Purity

98.0

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

NCCOP(OC[C@H](OC(CC(C)CCCC(C)CCCC(C)CCCC(C)C)=O)COC(CC(C)CCCC(C)CCCC(C)CCCC(C)C)=O)(O)=O

Molecular Formula

C45H90NO8P

Molecular Weight

804.17

Precautions

H225, H302, H310, H315, H319, H331, H351, H361, H370, H372

References & Citations

[1]Ferrari ME, et al. Synergy between cationic lipid and co-lipid determines the macroscopic structure and transfection activity of lipoplexes. Nucleic Acids Res. 2002 Apr 15;30 (8) :1808-16.|[2]Hartikka J, et al. Vaxfectin enhances the humoral immune response to plasmid DNA-encoded antigens. Vaccine. 2001 Feb 28;19 (15-16) :1911-23.