YUKA1

YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM. YUKA1 has less inhibitory active on KDM5C (IC50 = 7.12 μM) and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 can increase H3K4me3 levels and inhibit cell proliferation. YUKA1 can be used for the research of cancer, such as lung and breast cancers[1].

Product Specifications

CAS Number

[708991-09-7]

UNSPSC

12352005

Target

Histone Demethylase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/yuka1.html

Purity

99.15

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C=CCOC1=C(CNN2C(NN=C2)=S)C=CC=C1OC

Molecular Formula

C13H16N4O2S

Molecular Weight

292.36

References & Citations

[1]Gale M, et al. Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance. Oncotarget. 2016 Jun 28;7 (26) :39931-39944.