Dalmelitinib
Product Specifications
CAS Number
1637658-98-0
Target
Others, c-Met/HGFR
Related Pathways
Tyrosine Kinase/Adaptors, Others
Bioactivity
Dalmelitinib is a selective, orally active c-Met kinase inhibitor (IC50: 2.9 nM) that binds the ATP-binding region of c-Met. Dalmelitinib induces phosphorylation of MET and partially or completely inhibits phosphorylation of AKT and ERK. dalmelitinib exhibits a potent inhibitory effect on the proliferation of cancer cells (c-Met oncogene amplification) and can be used in cancer research (e.g. non-small cell lung cancer) .
Smiles
S(C1=CC2=C3C(=CN=C2C=C1)N(C)C(=O)CO3)C=4N5C(=NN4)C(F)=CC(=C5)C6=CN(C)N=C6
Molecular Formula
C22H16FN7O2S
Molecular Weight
461.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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