Thailanstatin D
Product Specifications
CAS Number
1609105-89-6
Target
Apoptosis|||Others|||DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Apoptosis|||Others
Bioactivity
Thailanstatin D, an analogue of Thailanstatin A, inhibits AR-V7 gene splicing by disrupting the interaction between U2AF65 and SAP155, hindering their binding to the polypyrimidine tract situated between the branch point and the 3' splice site. This compound displays potent tumor inhibitory properties in human castration-resistant prostate cancer (CRPC) xenografts, resulting in cellular apoptosis.
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C[C@H](OC(C)=O)\C=C/C(=O)N[C@@H]1C[C@H](C)[C@H](C\C=C(/C)\C=C\[C@@H]2C[C@]3(CO3)C[C@@H](CC(O)=O)O2)O[C@@H]1C
Molecular Formula
C28H41NO8
Molecular Weight
519.635
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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