Col003

Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen binding site on Hsp47 (IC50=1.8 μM) . Col003 discourages the interaction of Hsp47 with collagen and inhibits collagen secretion by destabilizing the collagen triple helix. Col003 can be used for the investigation of fibrosis[1]

Product Specifications

CAS Number

[328565-16-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/col003.html

Purity

99.87

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=CC1=CC(CC2=CC=CC=C2)=CC([N+]([O-])=O)=C1O

Molecular Formula

C14H11NO4

Molecular Weight

257.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Ito S, et al. A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis. J Biol Chem. 2017 Dec 8;292 (49) :20076-20085.