Col003
Product Specifications
UNSPSC Description
Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen binding site on Hsp47 (IC50=1.8 μM). Col003 discourages the interaction of Hsp47 with collagen and inhibits collagen secretion by destabilizing the collagen triple helix. Col003 can be used for the investigation of fibrosis[1]
Target Antigen
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/col003.html
Purity
99.87
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=CC1=CC(CC2=CC=CC=C2)=CC([N+]([O-])=O)=C1O
Molecular Weight
257.24
References & Citations
[1]Ito S, et al. A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis. J Biol Chem. 2017 Dec 8;292(49):20076-20085.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-124817/Col003-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-124817/Col003-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
328565-16-8
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Eph receptor A1 (EPHA1) Mouse Monoclonal Antibody [Clone ID: LBI2D6]](https://cdn.genprice.uk/genprice/genprice2.png)
AMM19160VCF 100 µg
Eph receptor A1 (EPHA1) Mouse Monoclonal Antibody [Clone ID: LBI2D6]
Ask
View Details 
