GNE-6893

GNE-6893 is a potent and orally active HPK1 inhibitor. GNE-6893 can be used in research of cancer[1].

Product Specifications

CAS Number

[2415374-98-8]

UNSPSC

12352005

Target

MAP4K

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gne-6893.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=C(N)C(C=NC(NC(O[C@@H]2[C@H](COC2)C)=O)=C3)=C3C=C1C4=CN=C(OCCN5)C5=C4C

Molecular Formula

C23H24FN5O4

Molecular Weight

453.47

References & Citations

[1]Andreas S, et, al. A Convergent Synthesis of HPK1 Inhibitor GNE-6893 via Palladium-Catalyzed Functionalization of a Tetrasubstituted Isoquinoline. Org. Process Res. Dev. 2023;27 (3) :523-9.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MAP4K1/HPK1

Available Sizes

Curated Selection

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