IL1RA (IL1RN) (NM_000577) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses, particularly in the acute phase of infection and inflammation. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]
Synonyms
DIRA; ICIL-1RA; IL-1ra; IL-1ra3; IL-1RN; IL1F3; IL1RA; IRAP; MVCD4
Gene ID
3557
UniProt
P18510
Accession Number mRNA
NM_000577
Chromosomal Location
2q14.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Secreted Protein
Molecular Weight
17.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
IL1RN
Species
Human
Protein ID
NP_000568
Overview
Recombinant protein of human interleukin 1 receptor antagonist (IL1RN), transcript variant 3
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/3557
Uniprot URL
https://www.uniprot.org/uniprot/P18510
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000577
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000568
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