Antimycobacterial agent-8

Antimycobacterial agent-8 (Compound 49) is an inhibitor for DNA gyrase. Antimycobacterial agent-8 exhibits antibacterial activity against Mycobacterium tuberculosis and M. abscessus with MIC90 of 2.5 μM and 0.63 μM. Antimycobacterial agent-8 exhibits good plasma protein binding ability in mice[1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352005

Target

Bacterial; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antimycobacterial-agent-8.html

Smiles

CC(N1)=C(Cl)C(Cl)=C1C(NC2=NC3=C(OC(C)C4CCNCC4)C=C(C(O)=O)C=C3S2)=O

Molecular Formula

C21H22Cl2N4O4S

Molecular Weight

497.39

References & Citations

[1]Sterle M, et al., Development of narrow-spectrum topoisomerase-targeting antibacterials against mycobacteria. Eur J Med Chem. 2024 Jul 19;276:116693.