Minnelide

Minnelide is a prodrug of triptolide that shows potent antitumor activity in a number of tumor types, particularly in pancreatic cancer. Minnelide promotes apoptosis[1].

Product Specifications

CAS Number

[1254702-87-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/minnelide.html

Purity

99.91

Solubility

DMSO : 16.67 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@@]34[C@]([C@@H]5C[C@@]1([H])C6=C(C(OC6)=O)CC2)(O5)[C@@H]([C@](O7)(C(C)C)[C@@H]7[C@@H]3O4)OCOP(O[Na])(O[Na])=O

Molecular Formula

C21H25Na2O10P

Molecular Weight

514.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Noel P, et al. Triptolide and Its Derivatives as Cancer Therapies. Trends Pharmacol Sci. 2019 May;40 (5) :327-341.|[2]Chugh R, et al. A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer. Sci Transl Med. 2012 Oct 17;4 (156) :156ra139.