Belapectin
Belapectin (GR-MD-02) is a Galectin-3 (Gal-3) inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cell Apoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity Ki of 2.8 μM[1][2].
Product Specifications
CAS Number
1980787-47-0
Product Name Alternative
GR-MD-02
UNSPSC
12352211
Target
Apoptosis; Galectin
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/belapectin.html
Purity
99.33
Solubility
H2O : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
[Belapectin]
References & Citations
[1]Sturgill ER, et al. Galectin-3 inhibition with belapectin combined with anti-OX40 therapy reprograms the tumor microenvironment to favor anti-tumor immunity. Oncoimmunology. 2021 Mar 1;10 (1) :1892265. |[2]Capasso D, et al. Galectins detection for the diagnosis of chronic diseases: An emerging biosensor approach[J]. TrAC Trends in Analytical Chemistry, 2023: 116952.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
Galectin-3
Available Sizes
Frequently Asked Questions
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