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HRI Antibody

Product Specifications

Background

The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands. Studies in rat and rabbit suggest that the HRI gene product phosphorylates the alpha subunit of eukaryotic initiation factor 2. Its kinase activity is induced by low levels of heme and inhibited by the presence of heme.

NCBI Gene ID

27102

Swiss Prot

Q9BQI3

Accession Number

Q9BQI3

Host

Rabbit

Reactivity

Human

Immunogen

This HRI (EIF2AK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-296 amino acids from the Central region of human HRI (EIF2AK1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

71 kDa

Fragment

Rabbit Ig

Symbol

EIF2AK1

NCBI Official Name

Eukaryotic translation initiation factor 2-alpha kinase 1

NCBI Organism

Homo sapiens

Background Reference 01

Hwang S.-Y., Mol. Cells 10:584-591 (2000) .

Background Reference 02

Omasa T., DNA Seq. 13:133-137 (2002) .

Other Product Names

Eukaryotic translation initiation factor 2-alpha kinase 1, Heme-controlled repressor, HCR, Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase, Heme-regulated inhibitor, Hemin-sensitive initiation factor 2-alpha kinase, EIF2AK1, HRI, KIAA1369

Tested Applications

WB, IHC-P

Protein ID

32172458

Physical Properties

Liquid

Frequently Asked Questions

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