HRI Antibody
Product Specifications
Background
The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands. Studies in rat and rabbit suggest that the HRI gene product phosphorylates the alpha subunit of eukaryotic initiation factor 2. Its kinase activity is induced by low levels of heme and inhibited by the presence of heme.
NCBI Gene ID
27102
Swiss Prot
Q9BQI3
Accession Number
Q9BQI3
Host
Rabbit
Reactivity
Human
Immunogen
This HRI (EIF2AK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-296 amino acids from the Central region of human HRI (EIF2AK1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=63-402
Calculated Molecular Weight
71 kDa
Fragment
Rabbit Ig
Symbol
EIF2AK1
NCBI Official Name
Eukaryotic translation initiation factor 2-alpha kinase 1
NCBI Organism
Homo sapiens
Background Reference 01
Hwang S.-Y., Mol. Cells 10:584-591 (2000) .
Background Reference 02
Omasa T., DNA Seq. 13:133-137 (2002) .
Other Product Names
Eukaryotic translation initiation factor 2-alpha kinase 1, Heme-controlled repressor, HCR, Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase, Heme-regulated inhibitor, Hemin-sensitive initiation factor 2-alpha kinase, EIF2AK1, HRI, KIAA1369
Tested Applications
WB, IHC-P
Protein ID
32172458
Physical Properties
Liquid
Curated Selection
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