Lumichrome

Lumichrome, a photodegradation product of Riboflavin, is an endogenous compound in humans. Lumichrome inhibits human lung cancer cell growth and induces apoptosis via a p53-dependent mechanism. Lumichrom is the inhibitor for AKT/β-catenin signaling pathway[1][2].

Product Specifications

CAS Number

[1086-80-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Akt; Apoptosis; ERK; MDM-2/p53; NF-κB; Nuclear Factor of activated T Cells (NFAT) ; p38 MAPK; β-catenin

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/lumichrome.html

Purity

99.72

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N1)NC2=NC3=CC(C)=C(C)C=C3N=C2C1=O

Molecular Formula

C12H10N4O2

Molecular Weight

242.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Bergh VJ, et al. Influence of formulation on photoinactivation of bacteria by lumichrome. Pharmazie. 2015;70 (9) :574-580. |[2]Chantarawong W, et al. Lumichrome Inhibits Human Lung Cancer Cell Growth and Induces Apoptosis via a p53-Dependent Mechanism. Nutr Cancer. 2019;71 (8) :1390-1402. |[3]Liu C, et al., Lumichrome inhibits osteoclastogenesis and bone resorption through suppressing RANKL-induced NFAT activation and calcium signaling. J Cell Physiol. 2018 Nov;233 (11) :8971-8983.