SKLB4771
SKLB4771 is a potent and selective Flt3 inhibitor with an IC50 value of 10 nM. SKLB4771 downregulates the phosphorylation of FLT3/STAT5/ERK, blocks cell proliferation, and induces apoptosis in tumor tissue[1][2].
Product Specifications
CAS Number
1370256-78-2
Product Name Alternative
FLT3-IN-1
UNSPSC
12352005
Hazard Statement
H302, H315, H320, H335
Target
Apoptosis; c-Kit; FLT3
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SKLB4771.html
Purity
99.20
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C(NC1=NN=C(SC2=C3C=CC(OCCCN4CCOCC4)=CC3=NC=N2)S1)NC5=CC=C(C)C=C5
Molecular Formula
C25H27N7O3S2
Molecular Weight
537.66
Precautions
H302, H315, H320, H335
References & Citations
[1]Li WW, et al. Discovery of the novel potent and selective FLT3 inhibitor 1-{5-[7- (3- morpholinopropoxy) quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and its anti-acute myeloid leukemia (AML) activities in vitro and in vivo. J Med Chem. 2012 Apr 26;55 (8) :3852-66.|[2]Yan HX, et al. Accumulation of FLT3 (+) CD11c (+) dendritic cells in psoriatic lesions and the anti-psoriatic effect of a selective FLT3 inhibitor. Immunol Res. 2014 Oct;60 (1) :112-26.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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