PC190723

PC190723 is a bacterial cell division protein FtsZ inhibitor (IC50 = 55 nM) . PC 190723 prevents cell division. PC190723 has potent and selective bactericidal activity against staphylococci, including methicillin- and multi-drug-resistant Staphylococcus aureus. PC190723 induces nucleated assembly of Bs-FtsZ into single-stranded coiled protofilaments and polymorphic condensates. PC190723 can be studied in anti-bacterial infection research[1][2][3].

Product Specifications

CAS Number

951120-33-5

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pc190723.html

Purity

98.34

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

NC(C1=C(C(OCC2=NC3=C(S2)N=CC(Cl)=C3)=CC=C1F)F)=O

Molecular Formula

C14H8ClF2N3O2S

Molecular Weight

355.75

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]Buroni S, et al. The cell division protein FtsZ as a cellular target to hit cystic fibrosis pathogens. Eur J Med Chem. 2020 Mar 15;190:112132. |[2]Haydon DJ, et al. An inhibitor of FtsZ with potent and selective anti-staphylococcal activity. Science. 2008 Sep 19;321 (5896) :1673-5. |[3]Andreu JM, et al. The antibacterial cell division inhibitor PC190723 is an FtsZ polymer-stabilizing agent that induces filament assembly and condensation. J Biol Chem. 2010 May 7;285 (19) :14239-46.