Taniborbactam (hydrochloride)
Product Specifications
UNSPSC Description
Taniborbactam hydrochloride (VNRX-5133 hydrochloride) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam hydrochloride has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam hydrochloride is against Gram-negative bacteria[1][2].
Target Antigen
Bacterial; Beta-lactamase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/taniborbactam-hydrochloride.html
Purity
99.97
Solubility
DMSO : 200 mg/mL (ultrasonic)|H2O : 33.33 mg/mL (ultrasonic)
Smiles
OC(C1=C(OB(O)[C@@H](NC(C[C@@H]2CC[C@@H](NCCN)CC2)=O)C3)C3=CC=C1)=O.[H]Cl.[H]Cl
Molecular Weight
462.18
References & Citations
[1]Liu B ,et al. Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. J Med Chem. 2019 Dec 16.|[2]Krajnc A, et al. Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases. J Med Chem. 2019 Sep 26;62(18):8544-8556.Antimicrob Agents Chemother. 2021 Nov 22;AAC0167621.|Antimicrob Agents Chemother. 2023 May 31;e0033923.|Antimicrob Agents Chemother. 2024 Jan 4:e0133223.|Antimicrob Agents Chemother. 2024 Oct 4:e0077524.|Engineering. 2024 Apr 12.|Int J Antimicrob Agents. 2023 Nov 4:107030.|J Antimicrob Chemother. 2023 Mar 15;dkad061.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-109124A/Taniborbactam-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-109124A/Taniborbactam-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
2244235-49-0
Available Sizes
Curated Selection
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