L-2-Hydroxyglutaric acid (disodium)

L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2].

Product Specifications

CAS Number

[63512-50-5]

Product Name Alternative

(S) -2-Hydroxyglutaric acid (disodium)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Histone Demethylase; Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/l-2-hydroxyglutaric-acid-disodium.html

Purity

99.12

Solubility

H2O : 83.33 mg/mL (ultrasonic)

Smiles

O=C(O[Na])[C@@H](O)CCC(O[Na])=O

Molecular Formula

C5H6Na2O5

Molecular Weight

192.08

Precautions

H302, H315, H319, H335

References & Citations

[1]Shim EH, et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014 Nov;4 (11) :1290-8.|[2]da Silva CG, et al. L-2-hydroxyglutaric acid inhibits mitochondrial creatine kinase activity from cerebellum of developing rats. Int J Dev Neurosci. 2003 Jun;21 (4) :217-24.