(R, R) -CXCR2-IN-2
(R, R) -CXCR2-IN-2, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively[1].
Product Specifications
CAS Number
[1838123-22-0]
UNSPSC
12352005
Target
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/r-r-cxcr2-in-2.html
Concentration
10mM
Purity
99.37
Solubility
DMSO : 220 mg/mL (ultrasonic)
Smiles
O=S(C1=C(C(NC(N[C@H]2C(C)=CCC2)=O)=CC=C1Cl)O)([C@@]3(CCOC3)C)=O
Molecular Formula
C18H23ClN2O5S
Molecular Weight
414.90
References & Citations
[1]Lu H, et al. Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists. J Med Chem. 2018;61 (6) :2518-2532.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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