Ebiratide
Ebiratide (HOE-427 free base) is an ACTH 4-9 derivative, which acts directly on the central nervous system and exhibits memory-enhancing efficacy. Ebiratide enhances acetycholine (ACh) metabolism in rat brain[1][2].
Product Specifications
CAS Number
105611-68-5
Product Name Alternative
HOE-427 (free base)
UNSPSC
12352209
Target
Melanocortin Receptor; nAChR
Type
Peptides
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ebiratide.html
Solubility
10 mM in DMSO
Smiles
NCCCCCCCCNC([C@H](CC1=CC=CC=C1)NC([C@@H](CCCCN)NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@@H](N)CCS(C)(=O)=O)=O)=O)CC3=CN=CN3)=O)=O)=O)=O
Molecular Formula
C48H73N11O10S
Molecular Weight
996.23
References & Citations
[1]Hock FJ, et al., Learning and memory processes of an ACTH4-9 analog (ebiratide; Hoe 427) in mice and rats. Peptides. 1988 May-Jun;9 (3) :575-81. |[2]G Wiemer, et al. Neurochemical effects of the synthetic ACTH4-9-analog Hoe 427 (Ebiratide) in rat brain. Peptides. 1988 Sep-Oct;9 (5) :1081-7.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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