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HDAC-IN-82

HDAC-IN-82 (Compound 18b) is a histone deacetylase (HDAC) inhibitor with selective antiplasmodial and anticancer activity. HDAC-IN-82 shows potent antiproliferative activity and caspase 3/7 activation in cancer cells. HDAC-IN-82 causes hyperacetylation of histone H3 and α-tubulin[1].

Product Specifications

UNSPSC

12352005

Target

Caspase; HDAC; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdac-in-82.html

Smiles

O=C(C1=CN=C(N2CCC(CN(C3(C(NCC4=CC=CC=C4)=O)CNCC3)C=O)CC2)N=C1)NO

Molecular Formula

C24H31N7O4

Molecular Weight

481.55

References & Citations

[1]Stopper D, et al. Multicomponent syntheses enable the discovery of novel quisinostat-derived chemotypes as histone deacetylase inhibitors. Eur J Med Chem. 2025 Jan 5;281:117045.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Caspase 3; Caspase 7

Frequently Asked Questions

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