N-Cadherin Mouse Monoclonal Antibody [A10-4]
The cadherins are a large family of cell adhesion molecules involved in calcium-dependent recognition and adhesion events. The cadherin subfamily includes N-, P-, B-, and E- cadherins, and other members. Recent studies indicate that cancer cells have up-regulated N-cadherin in addition to loss of E-cadherin. This change in cadherin expression is called the "cadherin switch". N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion.
Product Specifications
Product Name Alternative
Abbreviation
N-cadherin
Swiss Prot
P19022 Human
Cellular Locus
Cell membrane.
Host
Mouse
Species Reactivity
Human,Mouse
Immunogen
Recombinant protein within Human N-Cadherin aa 401-600 / 906.
Isotype
IgM
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
Mouse heart tissue lysate, human heart tissue lysate.
Concentration
2 mg/mL
Dilution
WB: 1:1,000-1:2,000 ;IF-Cell: 1:500 ;IHC-P: 1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 100 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No
CAS Number
9007-83-4
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