Cosdosiran
Cosdosiran is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.
Product Specifications
CAS Number
[1834560-88-1]
Product Name Alternative
QPI-1007
UNSPSC
12352208
Target
Caspase; Small Interfering RNA (siRNA)
Type
Oligonucleotides
Related Pathways
Apoptosis; Epigenetics
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cosdosiran.html
Purity
98.48
Solubility
10 mM in H2O
Smiles
[Cosdosiran]
References & Citations
[1]Solano EC, Kornbrust DJ, Beaudry A, Foy JW, Schneider DJ, Thompson JD. Toxicological and pharmacokinetic properties of QPI-1007, a chemically modified synthetic siRNA targeting caspase 2 mRNA, following intravitreal injection. Nucleic Acid Ther. 2014;24 (4) :258-266. doi:10.1089/nat.2014.0489
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 3
Available Sizes
Curated Selection
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