CRT0066854 (hydrochloride)

CRT0066854 hydrochloride is a potent and selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively[1].

Product Specifications

CAS Number

[2250019-91-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

PKC; ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; Stem Cell/Wnt; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/crt0066854-hydrochloride.html

Purity

99.29

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N[C@H](CNC1=NC(C2=CC=NC=C2)=NC3=C1C(CCCC4)=C4S3)CC5=CC=CC=C5.[H]Cl

Molecular Formula

C24H26ClN5S

Molecular Weight

452.01

Precautions

H315, H319, H320

References & Citations

[1]Kjær S, et al. Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes. Biochem J. 2013 Apr 15;451 (2) :329-42.