Anti-HDAC5 (Phospho-Ser498)
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Product Specifications
CAS Number
9007-83-4
Reactivity
Human,Mouse,Rat
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human HDAC5 around the phosphorylation site of serine 498 (T-Q-SP-S-P).
Clonality
Polyclonal
Type
Antibodies-Polyclonal
Applications
WB,IHC
Concentration
1ug/ul
Purity
Buffer
phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Shipping Conditions
Ice Pack
Storage Conditions
Specificity
HDAC5 (phospho-Ser498) antibody detects endogenous levels of HDAC5 only when phosphorylated at serine 498.
Applications Notes
WB: 1:500~1:1000 IHC: 1:50~1:100
Frequently Asked Questions
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