Rabbit anti Human Orexin Receptor-1 (N Terminal)

As first published in 1998 by Sakurai et al,, the initial neuropeptides Orexin A and Orexin B were shown to be important in the regulation of appetite. Continued research now suggests that these peptides also influence a wide range of physiological and behavioral processes such as increased EFG arousal and wakefulness and locomotor activity. In addition to the orexins , two G-protein coupled receptors, designated orexin receptor-1 and orexin receptor-2, have been identified which presumably mediate the signaling events from these neuropeptides1. Recently Orexin Receptors have been found to activate extracellular signal-regulated kinases in CHO cells, namely ERK phosporylation, through Ca2+ influx..2. Further studies seem to indicate a mechanism for orexin receptor mediated cell death and suggest a pathway from GPCRÕs to apoptosis throughthe MAPK pathways.3

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

1. Rodger, R. J. et al, Orexins and Appetite Regularion, Neuropeptides,(2002) Vol 36, pp.303-325. 2.Ammoun, Sylvia et al., OX1 Orexin Receptors Activate Extracellular Signal-Regulated Kinase in Chinese Hamster Ovary Cells via Multiple Mechanisms: The Role of Ca2+ Influx in OX1 Receptor Signaling. Molecular Endocrinology, 2006, Issue 20, vol 1, pp.80-99 3. Ammoun, Sylvia et al. G- protein couples OX1 Orexin/hcrtr-1 Hypocretin Recptors Induce Caspase-dependent and -independent Cell Death through p38 Mitogen-/Stress-activated Protein Kinase, J. Biol. Chem, January 13, 2006, Vol 281, Issue 2, pp834-843,