PDE4B/D-IN-4
Product Specifications
UNSPSC Description
PDE4B/D-IN-4 (compound 4p) is a potent inhibitor of PDE-4B and PDE-4D, with IC50s of 5.50 nM and 6.81 nM, respectively. PDE4B/D-IN-4 shows an increase in the level of intracellular cAMP[1].
Target Antigen
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pde4b-d-in-4.html
Smiles
O=C(N/N=C/C1=CC=C(OC)C(O)=C1)C2=CC=C(OC(F)F)C(OCC3CC3)=C2
Molecular Weight
406.38
References & Citations
[1]Ahmed M Moussa, et al. Rationale design and synthesis of new roflumilast analogues as preferential selective and potent PDE-4B inhibitors. Bioorg Chem. 2024 Oct 24:153:107911
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168558/PDE4B-D-IN-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168558/
Clinical Information
No Development Reported
Curated Selection
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