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Virodhamine (TFA)

Virodhamine TFA is an endocannabinoid, it regulates neurotransmission by activating the cannabinoid (CB) receptors. Virodhamine is an antagonist of CB1 receptor and an agonist of CB2 receptor. Virodhamine TFA induces megakaryocytic differentiation by triggering MAPK signaling and ROS production. Virodhamine TFA can be used for the research of various neurological disorders such as Alzheimer's and Parkinson's diseases[1][2].

Product Specifications

CAS Number

1415264-56-0

UNSPSC

12352211

Target

Cannabinoid Receptor; Endogenous Metabolite

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/virodhamine-tfa.html

Smiles

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(OCCN)=O.OC(C(F)(F)F)=O

Molecular Formula

C24H38F3NO4

Molecular Weight

461.56

References & Citations

[1]Sharma DS, et al. Virodhamine, an endocannabinoid, induces megakaryocyte differentiation by regulating MAPK activity and function of mitochondria. J Cell Physiol. 2021 Feb;236 (2) :1445-1453.|[2]Hayase T. Working memory- and anxiety-related behavioral effects of repeated nicotine as a stressor: the role of cannabinoid receptors. BMC Neurosci. 2013 Feb 9;14:20.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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