PM050489
Product Specifications
CAS Number
960210-97-3
UNSPSC Description
PM050489 is an effective polyketone inhibitor of Microtubule/Tubulin that can be isolated from Madagascan sponge Lithoplocamia lithistoides. PM050489 inhibits mitosis with an IC50 value of 26.4 nM. PM050489 has antitumor activity and can be used in cancer research[1][2].
Target Antigen
Microtubule/Tubulin
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pm050489.html
Solubility
10 mM in DMSO
Smiles
C/C(Cl)=C\C[C@H](OC(N)=O)C/C=C\NC([C@H](C(C)(C)C)NC(/C=C\C=C/C(C)=C/[C@@H]([C@@]1([H])OC(C(OC)=CC1)=O)C)=O)=O
Molecular Weight
606.15
References & Citations
[1]Martín MJ, et al. Isolation and first total synthesis of PM050489 and PM060184, two new marine anticancer compounds. J Am Chem Soc. 2013 Jul 10;135(27):10164-71. |[2]Pera B, et al. New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism. ACS Chem Biol. 2013 Sep 20;8(9):2084-94.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
Frequently Asked Questions
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