GRB7 Recombinant Rabbit Monoclonal Antibody [JE50-05]
Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
Growth factor receptor-bound protein 7 B47 Epidermal growth factor receptor GRB-7 GRB7 adapter protein GRB7
Swiss Prot
Q14451 Human
Cellular Locus
Cell junction. Cell membrane.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within Human GRB7 aa 1-150 / 532.
Isotype
IgG
Clone
JE50-05
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P, IF-Cell, FC
Positive Control
A431 cell lysate, HepG2 cell lysate, SK-Br-3 cell lysate, human breast cancer tissue, human kidney tissue, SK-Br-3.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:500-1:2,000 ;IF-Cell: 1:100 ;FC: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 60 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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