Menthol

Product Specifications

CAS Number

[1490-04-6]

UNSPSC Description

Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca++ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice[1][2][3].

Target Antigen

Calcium Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel;Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/menthol.html

Purity

99.44

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

OC1C(C(C)C)CCC(C)C1

Molecular Weight

156.27

References & Citations

[1]NicolettaGaleotti, et al. Menthol: a natural analgesic compound. Neuroscience Letters. 2002 Apr.|[2]Ha MA, et al. Menthol attenuates respiratory irritation and elevates blood cotinine in cigarette smoke exposed mice. PLoS One. 2015 Feb 13;10(2):e0117128.|[3]Fan L, et al. Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism. Tob Control. 2016 Nov;25(Suppl 2):ii50-ii54.