Restrictocin
Restrictocin is a small endoribonuclease. Restrictocin cleaves one site in the conserved sarcin/ricin loop (SRL) in 23S-28S rRNA to disrupt GTPase activation when elongation factors bind to the ribosome, halt protein synthesis, and ultimately trigger apoptotic cell death[1].
Product Specifications
CAS Number
[1406-72-0]
UNSPSC
12352204
Hazard Statement
H302+H312+H332-H317-H334
Target
Apoptosis; Endonuclease
Type
Enzyme
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/restrictocin.html
Solubility
10 mM in DMSO
Smiles
[Restrictocin]
Precautions
P261-P264-P270-P271-P272-P280-P284-P302+P352-P304+P340-P330-P362+P364-P501
References & Citations
[1]Plantinga MJ, et al. The ribotoxin restrictocin recognizes its RNA substrate by selective engagement of active site residues. Biochemistry. 2011 Apr 12;50 (14) :3004-13.
Shipping Conditions
Room temperature
Scientific Category
Enzyme
Clinical Information
No Development Reported
Curated Selection
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