SYNE3 Antibody (C-term) [APR30683G]
Product Specifications
Background
Tissue Location: Expressed in aortic endothelial cells (at protein level) .
Synonyms
Nesprin-3, Nuclear envelope spectrin repeat protein 3, SYNE3, C14orf49
Gene Name
HGNC:19861
Gene ID
161176
UniProt
Q6ZMZ3
Chromosomal Location
Nucleus outer membrane; Single-pass type IV membrane protein. Nucleus envelope. Rough endoplasmic reticulum
Applications
WB, IHC-P
Dilution
WB--1:1000 IHC-P--1:100~500
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.
Molecular Weight
112216
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SYNE3 Antibody (C-term) [APR30683G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=161176
Uniprot URL
https://www.uniprot.org/uniprot/Q6ZMZ3
Available Sizes
Curated Selection
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