Dauricumine
Dauricumine is a chlorinated alkaloid that inhibits NF-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts[1][2].
Product Specifications
CAS Number
345641-00-1
UNSPSC
12352005
Target
NF-κB
Type
Natural Products
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/dauricumine.html
Solubility
10 mM in DMSO
Smiles
COC([C@@]12[C@](C3)(CCN2C)[C@@]4([C@H](C1)Cl)[C@H](C(OC)=CC4=O)O)=C(OC)C3=O
Molecular Formula
C19H24ClNO6
Molecular Weight
397.85
References & Citations
[1]Sugimoto Y, et, al. Chlorinated alkaloids in Menispermum dauricum DC: root culture. J Org Chem. 2001 May 18;66 (10) :3299-302.|[2]Lee JY, et, al. Anti-osteoclastogenic effects of isoquinoline alkaloids from the rhizome extract of Sinomenium acutum. Arch Pharm Res. 2016 May;39 (5) :713-20.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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