Recombinant Phospho-PTP1B (Ser386) Monoclonal Antibody
Product Specifications
Background
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
Abbreviation
Phospho-PTP1B (Ser386)
UniProt
P18031
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human Phospho-PTP1B (Ser386) fragment
Target
PTPN; PTPN1; PTP1B
Clonality
Monoclonal,Recombinant
Clone
A346
Conjugation
Unconjugated
Applications
WB; IF
Field of Research
Signal Transduction; Cardiovascular
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000; IF 1:50
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
50 kDa
Observed Molecular Weight
50 kDa
Isotype
IgG, κ
Available Sizes
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