Antipyrine

Antipyrine (Phenazone) is an orally active antipyretic and analgesic. Antipyrine can be used as a probe agent for oxidative agent metabolism. Antipyrine also delays gastric emptying (GE) in rats[1][2][3][4].

Product Specifications

CAS Number

[60-80-0]

Product Name Alternative

Phenazone; Phenazon

UNSPSC

12352005

Hazard Statement

H302

Target

Fluorescent Dye; GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Antipyrine.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=C1N(C2=CC=CC=C2)N(C)C(C)=C1

Molecular Formula

C11H12N2O

Molecular Weight

188.23

Precautions

H302

References & Citations

[1]Stevenson, I.H., Factors influencing antipyrine elimination. Br J Clin Pharmacol, 1977. 4 (3) : p. 261-5.|[2]Engel G, et, al. Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation. Clin Pharmacol Ther. 1996 Jun;59 (6) :613-23.|[3]RENKIN EM. Capillary and cellular permeability to some compounds related to antipyrine. Am J Physiol. 1953 Apr;173 (1) :125-30.|[4]Soares AC, et al. Effect of antipyrine on the gastric emptying of liquid in rats. Braz J Med Biol Res. 2006 Nov;39 (11) :1507-12.