TAS-119

TAS-119 is a potent, selective and orally active Aurora A inhibitor with an IC50 of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM) . TAS-119 has potent antitumor activites[1].

Product Specifications

CAS Number

[1453099-83-6]

UNSPSC

12352005

Target

Aurora Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tas-119.html

Purity

98.01

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1(CC2=NC(NC3=NNC(C)=C3)=C(F)C=C2)CCN(C(C4=CC=CC(Cl)=C4Cl)=O)CC1)O

Molecular Formula

C23H22Cl2FN5O3

Molecular Weight

506.36

References & Citations

[1]Hiroshi Sootome, et al. Aurora A Inhibitor TAS-119 Enhances Antitumor Efficacy of Taxanes In Vitro and In Vivo: Preclinical Studies as Guidance for Clinical Development and Trial Design. Mol Cancer Ther. 2020 Oct;19 (10) :1981-1991.