RANK-derived TRAF6 inhibitor
RANK-derived TRAF6 inhibitor is a TRAF6 inhibitor peptide that blocks the interaction of TRAF6 and LMP1 with an IC50 of 177 nM. RANK-derived TRAF6 inhibitor causes a severe reduction in cell viability in the LMP1-dependent lymphoblastoid cell lines (LCLs) [1].
Product Specifications
CAS Number
[1393741-66-6]
UNSPSC
12352209
Target
TNF Receptor
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCSC)C(N[C@@H](CCCCN)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(N6[C@@H](CCC6)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC7=CC=C(C=C7)O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N
Molecular Formula
C158H250N48O40S
Molecular Weight
3494.04
References & Citations
[1]Fabian Giehler, et al. Epstein-Barr virus-driven B cell lymphoma mediated by a direct LMP1-TRAF6 complex. Nat Commun. 2024 Jan 10;15 (1) :414.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6420636-01 0.1 mL
Histone H3.1 (HIST1H3J, Histone H3K4me3, H3/j, H3FJ, Histone H3/a, Histone H3/b,Histone H3/c, Histone H3/d, Histone H3/f,Histone H3/h, Histone H3/I,Histone H3/j, Histone H3/k, Histone H3/l, HIST3H3) (FITC)
Sign In for Pricing
View Details 
MBS6420636-02 5x 0.1 mL
Histone H3.1 (HIST1H3J, Histone H3K4me3, H3/j, H3FJ, Histone H3/a, Histone H3/b,Histone H3/c, Histone H3/d, Histone H3/f,Histone H3/h, Histone H3/I,Histone H3/j, Histone H3/k, Histone H3/l, HIST3H3) (FITC)
Sign In for Pricing
View Details 