(R) -Bicalutamide

(R) -Bicalutamide is the (R) -enantiomer of Bicalutamide (HY-14249) . (R) -Bicalutamide is an androgen receptor (AR) antagonist, with antineoplastic activity. (R) -Bicalutamide is widely used for the research of prostate cancer[1][2].

Product Specifications

CAS Number

[113299-40-4]

UNSPSC

12352005

Hazard Statement

H302

Target

Androgen Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/r-bicalutamide.html

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)[C@@](C)(O)CS(=O)(C2=CC=C(F)C=C2)=O

Molecular Formula

C18H14F4N2O4S

Molecular Weight

430.37

Precautions

H302

References & Citations

[1]Hongli Liu, et al. Molecular mechanism of R-bicalutamide switching from androgen receptor antagonist to agonist induced by amino acid mutations using molecular dynamics simulations and free energy calculation. J Comput Aided Mol Des. 2016 Dec;30 (12) :1189-1200.|[2]Sara Pignatta, et al. Prolonged exposure to (R) -bicalutamide generates a LNCaP subclone with alteration of mitochondrial genome. Mol Cell Endocrinol. 2014 Jan 25;382 (1) :314-324.|[3]Anna Tesei, et al. Effect of Small Molecules Modulating Androgen Receptor (SARMs) in Human Prostate Cancer Models. PLoS One. 2013; 8 (5) : e62657.