BCL2L1 Rabbit Polyclonal Antibody
Bcl-x, a member of the Bcl-2 protein family, inhibits cell death, or apoptosis. Bcl-x is expressed as two isomeric forms, Bcl-xL and Bcl-xS, and is typically present in the cytosol in association with the mitochondrial membrane. Bcl-xL forms heterodimers with various proteins, including Bax, Bak and Bcl-2. It appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
Bcl2-L-1
Swiss Prot
Q07817 Human
Cellular Locus
Mitochondrion membrane, nucleus membrane, cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Nucleus, Synapse.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within N-terminal human BCL2L1.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
Hela, A431 cell lysate, K562 cell lysate, human kidney tissue, mouse kidney tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000;IF-Cell: 1:100-1:200;IHC-P: 1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 26 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No
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