Cardiac Troponin T Mouse Monoclonal Antibody [5-C7]
Troponin, working in conjunction with tropomyosin, functions as a molecular switch, regulating muscle contraction in response to changes in the intracellular Ca2+ concentration. Troponin consists of three subunits: the Ca2+-binding subunit troponin C (TnC), the tropomyosin-binding subunit troponin T (TnT), and the inhibitory subunit troponin I (TnI).Troponin T type 2 (cTnT,TNNT2) is a cardiac troponin T isoform expressed in the human heart, that is essential for calcium-regulated myofibrillar ATPase activity. Assays for measuring serum concentrations of cTnT, as well as cTnI, have been reported for analyzing cardiac injury.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
TnTc,cTnT
Swiss Prot
P45379 Human, P50752 Mouse
Cellular Locus
Cytosol.
Host
Mouse
Species Reactivity
Human,Mouse
Immunogen
Synthetic peptide within human TNNT2 50-100 aa.
Isotype
IgG2b
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
Human heart tissue lysate, SK-Br-3, mouse heart tissue.
Concentration
2 mg/mL
Dilution
WB: 1:2,000-1:5,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 36 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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