NSUN2 Recombinant Rabbit Monoclonal Antibody [PSH05-05]

NOP2/Sun domain family, member 2 is a protein that in humans is encoded by the NSUN2 gene. Alternatively spliced transcript variants encoding different isoforms have been noted for the gene. The protein is a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA (Leu) (CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. NSUN2 is also localized on mitochondria and is capable of introducing post-transcriptional modifications in mitochondrial tRNAs. Mutations in this gene have been found associated to cases of Dubowitz-like syndrome.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

5 methycytoisine methyltransferase antibody D13Wsu123e antibody FLJ20303 antibody hTrm4 antibody MISU antibody Myc induced SUN domain containing protein antibody NOL1/NOP2/Sun domain family 2 antibody NOL1/NOP2/Sun domain family 2 protein antibody NOL1/NOP2/Sun domain family member 2 antibody NSUN 2 antibody NSUN2 antibody NSUN2_HUMAN antibody SAKI antibody Substrate of AIM1/Aurora kinase B antibody TRM4 antibody tRNA (cytosine 5 ) methyltransferase antibody tRNA (cytosine 5 ) methyltransferase NSUN2 antibody tRNA (cytosine (34)-C (5))-methyltransferase antibody tRNA (cytosine-5-)-methyltransferase antibody tRNA methyltransferase 4 homolo antibody tRNA methyltransferase 4 homolog antibody

Abbreviation

NSUN2, SAKI, TRM4

Swiss Prot

Q08J23 Human, Q1HFZ0 Mouse,

Cellular Locus

Nucleus, nucleolus, Cytoplasm, Mitochondrion, cytoskeleton, spindle, Secreted, extracellular exosome.

Host

Rabbit

Species Reactivity

Human,Mouse,Monkey

Immunogen

Recombinant protein within human NSUN2 aa1-767.

Isotype

IgG

Clone

PSH05-05

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, IF-Tissue, IP

Positive Control

HeLa cell lysate, HepG2 cell lysate, Jurkat cell lysate, HEK-293 cell lysate, 293T cell lysate, A431 cell lysate, HCT 116 cell lysate, Caco-2 cell lysate, Neuro-2a cell lysate, COS-1 cell lysate, human testis tissue, human small intestine tissue, HeLa.