PCBP1 Mouse Monoclonal Antibody [A3E10]
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP2 and HNRNPK corresponds to the major cellular poly (rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
Poly (rC)-binding protein 1 Alpha-CP1 Heterogeneous nuclear ribonucleoprotein E1 hnRNP E1 Nucleic acid-binding protein SUB2.3
Swiss Prot
Q15365 Human, P60335 Mouse
Cellular Locus
Cytoplasm, Nucleus.
Host
Mouse
Species Reactivity
Human,Mouse
Immunogen
Recombinant protein within human PCBP1 aa 1-356.
Isotype
IgG1
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IHC-P
Positive Control
Hela cell lysate, K562 cell lysate, Human colon cancer tissue.
Concentration
2 mg/mL
Dilution
WB: 1:2,000-1:5,000 ;IHC-P: 1:100-1:500
Purity
Protein G affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
37 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
Frequently Asked Questions
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