GPR161 Rabbit Polyclonal Antibody
Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
G protein coupled receptor 161 antibody G protein coupled receptor RE2 antibody RE2 antibody Gm208 G-protein coupled receptor 161
Abbreviation
GPR161
Swiss Prot
B2RPY5 Mouse
Cellular Locus
Cilium membrane, Cell membrane.
Host
Rabbit
Species Reactivity
Mouse,Rat
Immunogen
Recombinant protein within mouse GPR161 aa 323-545.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P
Positive Control
Mouse cerebellum tissue lysate, rat colon tissue lysate, rat uterus tissue, mouse kidney tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000 ;IHC-P: 1:50-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
60 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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