FKBP52 Recombinant Rabbit Monoclonal Antibody [JG96-30]
Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
PPIase FKBP4, FKBP51, 52 kDa FKBP, FKBP-52, p59, FKBP-4, HBI
Swiss Prot
Q02790 Human, P30416 Mouse
Cellular Locus
Cytoplasm. Cytoskeleton. Microtubule. Mitochondrion. Nucleus.
Host
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Recombinant protein within Human FKBP52 aa 1-132 / 459.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
SK-Br-3 cell lysate, 293 cell lysate, 293T, MCF-7, human prostate cancer tissue, human esophagus tissue, mouse brain tissue.
Concentration
1 mg/mL
Dilution
WB: 1:1,000-1:2,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 52 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
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